Origin: Italy, United States

Probiotics, also known as the “good bacteria” of the body, are microscopic living organisms intended to benefit our health by improving or restoring the gut flora.

While the use of probiotics for purported health benefits is far from new - dating back to Roman times! – their use is increasingly being studied for potential benefits such as preventing infections, boosting the immune system, maintaining healthy skin, and strengthening our nervous system. Much of the discussion emerging from the growing amount of probiotic research centers on the ability of probiotics to support gastrointestinal (GI) health. Ongoing research is also suggesting that a strong biochemical connection exists between gut and brain -- operating through the gut-brain axis -- thus the benefits of probiotics could extend to mental health in addition to physical health.

But not all probiotics are the same and different strains can impact the body differently. The American Gastroenterological Association states that not everybody benefits from the same probiotics. Based on our knowledge of ongoing probiotic research, along with our understanding of human metabolism, we chose to include a diverse combination of four specific and thoroughly-researched probiotic strains to provide a variety of benefits on digestive and overall health.


  • Promote a healthy GI tract
  • Strengthen the immune system
  • Support overall health

Science First

  1. “Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids.”

    - Gut Microbes, 2019.

  2. “Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults.”

    - Scandinavian Journal of Gastroenterology, 2011.

  3. “Bifidobacteria and Their Role as Members of the Human Gut Microbiota.”

    - Frontiers in Microbiology, 2016.

  4. “Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study.”

    - Beneficial Microbes, 2018.

  5. “The Effect of Bacillus subtilis DE111 on the Daily Bowel Movement Profile for People with Occasional Gastrointestinal Irregularity”

    - Journal of Probiotics & Health, 2017.

  6. “Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition.”

    - Neurobiology of Stress, 2019.

  7. “Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress.”

    - American Journal of Gastroenterology, 2019.

  8. “Psychobiotics: Changing the Mind with Gut Bacteria.”

    - American Journal of Gastroenterology, 2019.

  9. “Health Promoting Activities of Probiotics.”

    - Journal of Food Biochemistry, 2019.

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